INTERPLAY OF DRUG TRANSPORTERS AND ENZYMES ON HEPATIC DRUG PROCESSING - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 738

becomes more complex. A new pattern of change, depending on the distributions of
the enzyme and secretory transporter, surfaces with changes in CL influx (Table 23.8).
Nonetheless, the seesaw patterns in the clearances with changes in CL int would persist
for both PBPK and ZPBPK for drugs that undergo futile cycling (Table 23.8) and are
readily discerned with modeling and simulations. These types of ZPBPK models lend
great usefulness to decipher drug-drug interactions in liver and the type of changes
accompanying the use of inhibitors and inducers.
Acknowledgments
The work was supported by CIHR (MOP 64350).
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