Biomedical Engineering Reference
In-Depth Information
TABLE 22.5. Interactions of Flavonoids with BCRP
Flavonoid
Cell Line Used
Substrates
Effect on Pgp
Refs.
Flavones
Apigenin
MCF-7/MX100 and NCI-H460 MX20
K562/BCRP
Mitoxantrone
SN38
↑
Accumulation
Reverse resistance
34
164
Chrysin
MCF-7/MX100 and NCI-H460 MX20
K562/BCRP
Mitoxantrone
SN38
↑
Accumulation
Reverse resistance
34
164
Luteolin
MCF-7/MX100 and NCI-H460 MX20
K562/BCRP
Mitoxantrone
SN38
↑
Accumulation
Reverse resistance
34
164
Diosmetin
K562/BCRP
SN38
Reverse resistance
164
Diosmin
K562/BCRP
SN38
No effects
164
Flavonols
Fisetin
↑
MCF-7/MX100 and NCI-H460 MX20
K562/BCRP
Mitoxantrone
SN38
Accumulation
No effects
34
164
Galangin
K562/BCRP
SN38
Reverse resistance
164
Kaempferol
MCF-7/MX100 and NCI-H460 MX20
K562/BCRP
Mitoxantrone
Mitoxantrone/SN38
↑
Accumulation
Reverse resistance
34
164
Morin
MCF-7/MX100 and NCI-H460 MX20
Mitoxantrone
↔
Accumulation
34
Myricetin
MCF-7/MX100 and NCI-H460 MX20
K562/BCRP
Mitoxantrone
SN38
↔
Accumulation
No effects
34
164
Quercetin
MCF-7/MX100 and NCI-H460 MX20
MCF-7/MR and K562/BCRP
Mitoxantrone
Mitoxantrone/
prazosin
SN38
↑
Accumulation
↑
Accumulation
34
33
K562/BCRP
Moderate reversal
164
Rutin
K562/BCRP
SN38
No effects
164
Flavanones
Hesperitin
MCF-7/MX100 and NCI-H460 MX20
MCF-7/MR and K562/BCRP
Mitoxantrone
↑
Accumulation
↑
Accumulation
34
33
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