DIET/NUTRIENT INTERACTIONS WITH DRUG TRANSPORTERS - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 691

Flavanolols
Silibinin/
silymarin

Panc-1 cells (MRP1) DNM/VBL ↑ Accumulation 32

↓ GSH level

↓ Transport
↓ Efflux via MRP1
↓ Transport via MRP1
↓ Transport via MRP4
↑ Accumulation
↑ Accumulation

Vesicles from BHK-21-MRP1 cells
Human erythrocytes
Vesicles from human erythrocytes

LT C 4
BCPCF
DNP-SG
cGMP
Calcein
BCECF

160
163
188

HEK293-MRP1
HEK293-MRP5

Isoflavones
Biochanin A GLC 4 /ADR lung cancer cells (MRP1)

Panc-1 cells (MRP1)

Daunorubicin
DNM/VBL

↑ Accumulation
↑ Accumulation
↓ GSH level

182
32

Genistein GLC 4 /ADR lung cancer cells (MRP1) Daunorubicin ↑ Accumulation

↓ Transport
↑ Accumulation
↑ ATPase activity
↑ Accumulation
↑ ATPase activity
↓ Transport
↑ GSH transport
↑ Accumulation
↓

182
189
190
185
183

K562/TPA leukemia cells (MRP1)
Vesicles from GLC 4 /ADR cells
GLC 4 /ADR lung cancer cells/
membrane vesicles (MRP1)
Vesicles from HeLa-MRP1 cells
Vesicles from HeLa-MRP1 cells
Panc-1 cells (MRP1)

Adriamycin

Daunorubicin

LT C 4
Glutathione
DNM/VBL

146
184
32

GSH level

↓

Human erythrocytes BCPCF Efflux via MRP1 163

Genistin Vesicles from GLC 4 /ADR cells

GLC 4 /ADR lung cancer cells/
membrane vesicles (MRP1)

↔ ATPase activity 185

183

Daunorubicin ↔ Accumulation

↔ ATPase activity