DIET/NUTRIENT INTERACTIONS WITH DRUG TRANSPORTERS - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 670

TABLE 22.1. ( Continued )
Dietary

In Vitro/

Supplement In Vivo Substrate Effects Mechanisms Refs.

Ginseng In vitro Rhodamine 123/ ↑ Accumulation Inhibition of Pgp 114

vinblastine ↔ Pgp mRNA or

protein levels

Azidopine ↓ Photoaffinity labeling

↑ Accumulation

In vitro Daunorubicin Inhibition of Pgp 115

↔

Pgp protein level

Azidopine ↓ Photoaffinity labeling

Milk thistle In vitro Daunomycin ↑ Accumulation Inhibition of Pgp 120

↓ ATPase activity

Azidopine ↓ Photoaffinity labeling

In vitro Digoxin/

vinblastine

↓ Efflux/ ↑ accumulation Inhibition of Pgp 121

In vitro Daunomycin/

vinblastine

↑ Accumulation Inhibition of MRP1 32

In vivo Digoxin ↔ C max , ↔ AUC 122

In vivo Indinavir ↔ C max , ↔ AUC 123-125

In vivo Irinotecan ↔ C max , ↔ AUC 127

Kava In vitro Calcein-AM ↑ Accumulation Inhibition of Pgp 132

In vivo Kawain ↑ AUC, ↑ C max Inhibition of Pgp/CYP3A4 133