DIET/NUTRIENT INTERACTIONS WITH DRUG TRANSPORTERS - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 669

In vitro Vinblastine/

saquinavir

↓ Efflux Inhibition of MRP2/Pgp 75

In vitro Fexofenadine ↓ Uptake Inhibition of OATP/oatp 25

In vitro Estrone 3-sulfate ↓ Uptake Inhibition of OATP-B 81

In vivo Cyclosporine ↑ AUC, ↑ C max Inhibition of Pgp/CYP3A4 82-84

In vivo Talinolol ↑ AUC, ↑ C max

↓ AUC, ↓ C max

Inhibition of Pgp
See the text

72
86

In vivo Fexofenadine ↓ AUC, ↓ C max Inhibition of OATP 25,91

In vivo Digoxin ↔ C max , ↔ AUC See the text 87,88

Garlic In vitro Ritonavir ↓ Efflux Inhibition of Pgp 48

In vitro ↓ Pgp protein level 96

In vivo ↓ Pgp protein level 96

In vivo ↑ Mrp2 protein level 97

↓ AUC, ↓ C max

In vivo Saquinavir/

ritonavir

Induction of Pgp/CYP3A4 98,99

Green tea In vitro Rhodamine 123 ↑ Accumulation Inhibition of Pgp 104

In vitro Doxorubicin ↓ Efflux Inhibition of Pgp 176

In vitro ↓ Pgp gene expression

↓ ATPase activity

105

In vitro Methotrexate ↓ Efflux Inhibition of MRP2 106

In vitro Estrone 3-sulfate ↓ Uptake Inhibition of OATP-B 110

( Continued )