POLYMORPHISMS OF DRUG TRANSPORTERS AND CLINICAL RELEVANCE - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 639

405 AML patients (136 for
expression)

Lymphoblast MDR1
expression, overall
survival, remission rate,
risk of relapse

3435CC associated with ↓
MDR1 expression and ↓
overall survival with a ↑
probability of risk of
relapse

130

Retrospective study of
HIV + patients

CD4 cell recovery Marginal association with

1236 genotype

202

210 epileptic patients Degree of drug resistance 1236C/2677G/3435C

haplotype increased risk of
drug resistance

152

66 cancer patients Hepatic elimination over 90

min

2677T and 3435T alleles
associated with ↓
elimination constant ( k H )
for hepatic elimination of
99m Tc-sestamibi

203

28 Caucasian patients with
solid tumors

Tipifarnib PK 1236C > T associated with ↑

AUC

204

65 cancer patients Irinotecan and SN-38 PK 1236C > T associated with

higher irinotecan and
SN-38 AUC

205

− 129T > C, 2677G > T/A 25 drug-resistant, 20

drug-sensitive Turkish
patients

Drug resistance or
sensitivity

No statistical association 206

(Ala893Ser/Thr),
3435C > T

25 early-onset, 70
late-onset Parkinson's
disease patients

Early vs. late onset No statistical association 156

3435C > T, intron 26,
+ 80T > C

28 HIV + patients Cellular AUC 3435TT > CT > CC nelfinavir

cellular AUC;

138