POLYMORPHISMS OF DRUG TRANSPORTERS AND CLINICAL RELEVANCE - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 638

TABLE 21.2. ( Continued )
HUGO Outcome

Name SNP Population Marker Effect Ref.

15 healthy subjects Digoxin PK F lowest in 2677GG/3435CC,

intermediate in
2677GT/3435CT, and
highest in 2677TT/3435TT
subjects; renal CL highest
in 2677GG/3435CC
subjects and lowest in
2677TT/3435TT subjects

198

33 healthy Korean males Fexofenadine PK 2677AA/3435CC ↓

AUC(0-24 h) compared to
other genotypes; 3435TT
genotype ↑ AUC(0-24 h)
and C max compared to CC

128

101 Korean patients Lymphoblast Pgp function,

remission, 3-year
event-free survival

3435CC associated with ↓
Pgp activity; 3435CC,
2677GG, and
3435C/2677G haplotype
associated with complete
remission and 3-year
event-free survival but not
overall survival

199

52 children Vincristine PK and side

effects

No statistical association 200

+

411 drug-naive HIV Disease progression No statistical association 201

patients