DRUG TRANSPORT IN THE LIVER - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 375

Oatp2b1 (m) ↑× Nrf2 Oltipraz, ethoxyquin, butylated

hydroxyanisole

in vivo 268

Mrp2, 3, 5,
6 (m)

↑× AhR B-Naphthoflavone, PCB 126,

TCDD

in vivo 269

Mrp2, 3, 4, 6,
7 (m)

↑× Mrp4 CAR Phenobarbital, TCPOBOP in vivo 68,260,269

Mrp 2 (m) ↑× PXR RU486 in vivo 298

Mrp2 (m) ↑× CAR TCPOBOP Transgenic mice expressing only

humaninized CAR, Northern
blot

301

↑×

Mrp3 (m) PXR RU486 in vivo 298

Mrp3 (m) ↑× PXR PCN, spironolactone in vivo 68,269

Mrp3 (m) ↑× × PPAR Clofibrate, DEHP in vivo 121,269

Mrp4 (m) ↑× × PPAR Clofibrate in vivo 121

Bcrp (m) ↑× × PPAR Clofibrate in vivo 121

Mdr1a (m) ↑× × PPAR Clofibrate in vivo 121

Mrp2, 3, 4, 5,
6 (m)

↑× Nrf2 Oltipraz, ethoxyquin, butylated

hydroxyanisole

in vivo 269

Oatp2 (m) ↑× PXR LCA in vivo 270

Oatp2 (m) ↑× PXR PCN, 2-AAF in vivo 68,271,272

Oatp2 (m) ↑× CAR Phenobarbital, TCPOBOP in vivo 68

Bcrp (m) ↑× PXR 2-AAF in vivo 272

Mrp2 (m) ↑× PXR 2-AAF in vivo 272

Mdr2 (m) ↑× × PPAR Ciprofibrate in vivo 77

a DEHP, di(2-ethylhexyl) phthalate; PFDA, perfluorodecanoic acid; PCN, pregnenolone16

-carbonitrile; TCDD, 2,3,7,8-tetrachlorodibenzo- p -dioxin, TCPOBOP,
1,4-bis[2-(3,5-dichloropyridyloxy)]benzene; LCA, lithocholic acid; TSO, trans -stilbene oxide; 2-AAF, 2-acetylaminofluorene; CDCDA, chenodeoxycholic acid; DCA,
deoxycholic acid; LCA, lithocholic acid; DKCA, 5

-cholanic acid 3,7-dion; FAO, rat hepatoma cell line; LS174T, human colon carcinoma cell line; LS180, colon
cancer cell line; PCB, polychlorinated biphenyl; DEX, dexamethasone; 2-AAF, 2-acetylamino fluorene; AhR, aryl hydrocarbon receptor; Nrf2, nuclear factor-E2-related