DRUG TRANSPORT IN THE LIVER - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 374

TABLE 13.3. ( Continued )

Transport Induce/ Nuclear

Protein Repress RNA Protein Receptor Ligands Test System Refs.

Mrp3 (r) ↑ ×× CAR Phenobarbital, PCB 99, diallyl

sulfide, TSO

in vivo 69,155,263,264

Mrp3 (r) ↑ ×× Nrf2 Oltipraz in vivo 263,264

Mrp4 (r) ↑ × Nrf2 Ethoxyquin, Oltipraz in vivo 302

Mdr1a (r) b ↑ × CAR Diallyl sulfide in vivo 265

Mdr1a (r) b ↑ × Nrf2 Oltipraz in vivo 265

Mdr1b (r) b ↑ × Ahr Indole 3-carbinol in vivo 265

Mdr1b (r) b ↑ × CAR PCB 99 in vivo 265

Bsep (r) ↑ × PXR DEX in vivo 262

Oatp2 (r) ↓ × AhR B-Naphthoflavone, indole

3-carbinol, TCDD, PCB 126

in vivo 122

Oatp2 (r) ↑ ×× CAR Phenobarbital, diallyl sulfide,

PCB 99

in vivo 122,266,267

Oatp2 (r) ↑ ×× PXR PCN, spironolactone, DEX in vivo 122,267

Oatp1a4 (r) ↑ × PXR DEX Rat hepatocytes 300

Ntcp (r) ↓ × PXR DEX Rat hepatocytes 300

Oatp3a1,
2b1 (m)

↑ × AhR B-Naphthoflavone, PCB 126,

TCDD

in vivo 268

Oatp1a1 (m) ↓ × CAR Phenobarbital, diallyl sulfide,

TCPOBOP

in vivo 268

Oatp1a4 (m) ↑ × PXR PCN, spironolactone in vivo 268

Oatp1a1, 1b2,
2a1, 2b1 (m)

↓ × PXR PCN, spironolactone, DEX in vivo 268

Oatp1a1, 1b2,
2a1, 2b1 (m)

↓ × PPAR Clofibrate, DEHP in vivo 268