MULTIDRUG RESISTANCE PROTEINS OF THE ABCC SUBFAMILY - Drug Transporters: Molecular Characterization and Role in Drug Disposition - page 273

TABLE 11.2. (Continued )
Substrate a Drug Resistance b K m ( μ M) Refs. Refs.

Chenodeoxycholylglycine
( + GSH) d

5.9 123

Chenodeoxycholyltaurine
( + GSH) d

3.6 123

Ursodeoxycholylglycine
( + GSH) d

12.5 123

Ursodeoxycholyltaurine
( + GSH) d

7.8 123

ADP 118

ABCC5
cGMP e

55 Cadmium chloride 54

cAMP e 55 Potassium antimonyl 54

5-Fluoro-2 -deoxyuridine
monophosphate

1100 127 6-Mercaptopurine 56

5-Fluorouridine
monophosphate

127 6-Thioguanine 56,127

2 -Deoxyuridine
monophosphate

127 PMEA e 56

Folate 1000 128 5-Fluorouracil 127

Methotrexate 1300 128 Methotrexate 127,128

Diglutamylated
methotrexate

700 128

ABCC6
BQ-123

57,58 Etoposide 57

Leukotriene C 4 ∼ 0.6 57,58 Teniposide 57

S -Glutathionyl
N -ethylmaleimide

∼ 282 58

S -Glutathionyl
2,4-dinitrobenzene

57

ABCC10
17 β -Glucuronosyl
estradiol

58 129 Docetaxel 130

Leukotriene C 4 129 Paclitaxel 130

Vincristine 130

Vinblastine 130

ABCC11
5-Fluoro-2 -deoxyuridine
monophosphate

131 5-Fluorouracil 131

Dehydroepiandrosterone
3-sulfate

13 60,132 5-Fluoro-2 -deoxyuridine 131

Estrone 3-sulfate > 150 60,132 5-Fluoro-5 -deoxyuridine 131

Leukotriene C 4 132 2 ,3 -Dideoxycytidine 131

( Continued )