Biomedical Engineering Reference
In-Depth Information
TABLE 11.2. (
Continued
)
Substrate
a
Drug Resistance
b
K
m
(
μ
M)
Refs.
Refs.
17
β
-Glucuronosyl estradiol
7.2
70
p
-Aminohippurate
880
98
Ochratoxin A
98
Cholecystokinin peptide
8.1
107
Estrone 3-sulfate
106
ABCC3
Leukotriene C
4
5.3
109
Etoposide
48,112
S
-Glutathionyl
2,4-dinitrobenzene
5.7
109
Teniposide
48,112
17
β
-Glucuronosyl estradiol
25.6
109-111
Methotrexate
112
Cholylglycine
248
109
Methotrexate
776
109,113
Folate
1960
113
Leucovorin
1740
113
Dehydroepiandrosterone
3-sulfate
46
110
Bilirubin
Monoglucuronosyl
110
Bisglucuronosyl
110
ABCC4
cGMP
e
9.7
51,116,118
PMEA
e
50,114,115
cAMP
e
44.5
51,116,118
Azidothymidine
114
17
β
-Glucuronosyl estradiol
30.3
51,116
Methotrexate
49
Folate
170
119
6-Thioguanine
50,116
Methotrexate
220
51,119
6-Mercaptopurine
116
Leucovorin
640
119
Ganciclovir
117
Dehydroepiandrosterone
3-sulfate
2
120
Topotecan
126
Prostaglandin E
1
2.1
121
Prostaglandin E
2
3.5
121,122
Prostaglandin F
2
α
12.6
122
Thromboxane B
2
9.9
122
Urate
1500
124
p
-Aminohippurate
160
125
Cholyltaurine (
+
GSH)
d
7.7
53
Cholyltaurine
(
3.8
53
+
S
-methylglutathione)
d
+
cholyltaurine)
d
2700
53
GSH (
S
-methyl-glutathione
(
1200
53
+
cholyltaurine)
d
Cholate (
+
GSH)
d
14.8
123
Cholylglycine (
+
GSH)
d
25.8
123
Deoxycholylglycine
(
+
GSH)
d
6.7
123
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