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Mak RH, Ferrando AA, Downing JR, Jacks T,
Horvitz HR, Golub TR (2005) MicroRNA
expression profi les classify human cancers.
Nature 435(7043):834-838
23. Hutvágner G, Simard MJ, Mello CC, Zamore
PD (2004) Sequence-specifi c inhibition of
small RNA function. PLoS Biol 2(4):E98
24. Krützfeldt J, Rajewsky N, Braich R, Rajeev KG,
Tuschl T, Manoharan M, Stoffel M (2005)
Silencing of microRNAs in vivo with
'antagomirs'. Nature 438(7068):685-689
25. Calin GA, Cimmino A, Fabbri M, Ferracin M,
Wojcik SE, Shimizu M, Taccioli C, Zanesi N,
Garzon R, Aqeilan RI, Alder H, Volinia S,
Rassenti L, Liu X, Liu CG, Kipps TJ, Negrini
M, Croce CM (2008) MiR-15a and miR-16-1
cluster functions in human leukemia. Proc Natl
Acad Sci U S A 105(13):5166-5171
26. Costa FF (2009) Non-coding RNAs and new
opportunities for the private sector. Drug
Discov Today 14(9-10):446-452
27. Li Y, He C, Jin P (2010) Emergence of chemi-
cal biology approaches to the RNAi/miRNA
pathway. Chem Biol 17(6):584-589
28. Thomas JR, Hergenrother PJ (2008) Targeting
RNA with small molecules. Chem Rev 108(4):
1171-1224
29. Zhang S, Chen L, Jung EJ, Calin GA (2010)
Targeting microRNAs with small molecules:
from dream to reality. Clin Pharmacol Ther
87(6):754-758
30. Du T, Zamore PD (2005) microPrimer: the
biogenesis and function of microRNA.
Development 132(21):4645-4652
31. Lee Y, Ahn C, Han J, Choi H, Kim J, Yim J,
Lee J, Provost P, Rådmark O, Kim S, Kim VN
(2003) The nuclear RNase III Drosha initiates
microRNA processing. Nature 425(6956):
415-419
32. Denli AM, Tops BB, Plasterk RH, Ketting RF,
Hannon GJ (2004) Processing of primary
microRNAs by the Microprocessor complex.
Nature 432(7014):231-235
33. Hutvágner G, McLachlan J, Pasquinelli AE,
Bálint E, Tuschl T, Zamore PD (2001) A cel-
lular function for the RNA-interference enzyme
Dicer in the maturation of the let-7 small tem-
poral RNA. Science 293(5531):834-838
34. Liu J, Carmell MA, Rivas FV, Marsden CG,
Thomson JM, Song JJ, Hammond SM, Joshua-
Tor L, Hannon GJ (2004) Argonaute2 is the
catalytic engine of mammalian RNAi. Science
305(5689):1437-1441
35. Winter J, Jung S, Keller S, Gregory RI,
Diederichs S (2009) Many roads to maturity:
microRNA biogenesis pathways and their regu-
lation. Nat Cell Biol 11(3):228-234
36. Jackson A, Linsley PS (2010) The therapeutic
potential of microRNA modulation. Discov
Med 9(47):311-318
37. Jackson AL, Linsley PS (2010) Recognizing
and avoiding siRNA off-target effects for target
identifi cation and therapeutic application. Nat
Rev Drug Discov 9(1):57-67
38. Astashkina A, Mann B, Grainger DW (2012) A
critical evaluation of in vitro cell culture models
for high-throughput drug screening and toxic-
ity. Pharmacol Ther 134(1):82-106
39. Lipinski C, Hopkins A (2004) Navigating
chemical space for biology and medicine.
Nature 432(7019):855-861
40. Gumireddy K, Young D, Xiong X, Hogenesch
J, Huang Q, Deiters A (2008) Small-molecule
inhibitors of microRNA miR-21 function.
Angew Chem Int Ed 47(39):7482-7484
41. Young D, Connelly C, Grohmann C, Deiters A
(2010) Small molecule modifi ers of MicroRNA
miR-122 function for the treatment of hepatitis
C virus infection and hepatocellular carcinoma.
J Am Chem Soc 132(23):7976-7981
42. Chandrasekhar S, Pushpavalli SN, Chatla S,
Mukhopadhyay D, Ganganna B, Vijeender K,
Srihari P, Reddy CR, Janaki Ramaiah M,
Bhadra U (2012) aza-Flavanones as potent
cross-species microRNA inhibitors that arrest
cell cycle. Bioorg Med Chem Lett 22(1):
645-648
43. Michlewski G, Guil S, Semple CA, Cáceres JF
(2008) Posttranscriptional regulation of miR-
NAs harboring conserved terminal loops. Mol
Cell 32(3):383-393
44. Guil S, Cáceres JF (2007) The multifunctional
RNA-binding protein hnRNP A1 is required
for processing of miR-18a. Nat Struct Mol Biol
14(7):591-596
45. Lünse CE, Michlewski G, Hopp CS,
Rentmeister A, Cáceres JF, Famulok M, Mayer
G (2010) An aptamer targeting the apical-loop
domain modulates pri-miRNA processing.
Angew Chem Int Ed Engl 49(27):4674-4677
46. Ellington AD (1994) RNA selection. Aptamers
achieve the desired recognition. Curr Biol
4(5):427-429
47. Krishnamurthy M, Simon K, Orendt AM, Beal
PA (2007) Macrocyclic helix-threading pep-
tides for targeting RNA. Angew Chem Int Ed
Engl 46(37):7044-7047
48. Lee Y, Hyun S, Kim HJ, Yu J (2008)
Amphiphilic helical peptides containing two
acridine moieties display picomolar affi nity
toward HIV-1 RRE and TAR. Angew Chem
Int Ed Engl 47(1):134-137
49. Chirayil S, Chirayil R, Luebke KJ (2009)
Discovering ligands for a microRNA precursor
with peptoid microarrays. Nucleic Acids Res
37(16):5486-5497
50. Kwon YU, Kodadek T (2007) Quantitative
evaluation of the relative cell permeability of
peptoids and peptides. J Am Chem Soc 129(6):
1508-1509
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