Hyaluronic Acid Incorporation into Scaffolds for Bone and Cartilage Regeneration - Hyaluronic Acid for Biomedical and Pharmaceutical Applications - page 36

Figure 2.5 Histological sections showing cross-section of bone
regeneration in a rat calvarial critical size defect that has been
filled with HA scaffolds with different degradation rates and
loaded with different growth factors after 6 weeks of healing.
(a) Control, fast degrading; (b) control, intermediate degrading;
(c) control, slow degrading; (d) fast degrading with 25 µg vascular
endothelial growth factor (VEGF); (e) fast degrading with 5 µg
BMP-2; (f) intermediate degrading with 5 µg BMP-2; (g) slow
degrading with 5 µg BMP-2; and (h) fast degrading with 25
µg VEGF and 5 µg BMP-2. Arrows indicate the original defect
margins. The clear regions in (c) and (g) result from the residual
(slow degrading) hydrogel. Reproduced with permission from J.
Patterson, R. Siew, S.W. Herring, A.S.P. Lin, R. Guldberg and P.S.
Stayton, Biomaterials , 2010, 31 , 6778. ©2010, Elsevier [77]