Biomedical Engineering Reference
In-Depth Information
Table 9.1: Binding and dissociation rate coefficients for different bradykinin concentrations in solution to a resonant waveguide
grating (RWG) biosensor (
Fang et al., 2006
).
Analyte in
Solution/Receptor
on Surface
k
k
1
k
2
k
d
k
d1
k
d2
10
5
10
5
128 nM
Bradykinin/RWG
biosensor
0.0300
0.0048
0.0199
0.0027
0.3579
0.0146
0.0020
0.0019
2.5
1.6
0.36
0
64 nM Bradykinin/
RWG biosensor
0.02331
0.00402
0.00952
0.0011
0.07470
0.00011 0.002138
0.00074
0.000471
0.00006
0.07464
0.00451
10
5
10
5
32 nM Bradykinin/
RWG biosensor
0.000491
þ
0.00076 0.002564
0.000014
0.0921
0.0018
0.000248
0.00015
1.8
0.4
0.14
0
10
5
10
5
10
6
10
6
16 nM Bradykinin/
RWG biosensor
0.00420
0.00053 0.002239
0.000144 0.02938
0.00204 6.2
4.4
4.3
3.2
0.72
0
8 nM Bradykinin/
RWG biosensor
0.00556 0.00091
0.00161 0.00025
0.08324 0.00059 0.000695 0.00017
na
na
Table 9.2: Fractal dimensions for the binding and the dissociation phase for different bradykinin concentrations in solution
to a resonant waveguide grating (RWG) biosensor (
Fang et al., 2006
).
Analyte in Solution/
Receptor on Surface
D
f
D
f1
D
f2
D
fd
D
fd1
D
fd2
0 þ 0.65025 3.0-2.4 10
15
128 nM Bradykinin/
RWG biosensor
1.646 0.2188
1.402 0.2508
2.7544 0.1618 1.4594 0.3538
64 nM Bradykinin/
RWG biosensor
1.7698 0.1624 1.2476 0.2316
2.2580 0.00758 1.5936 0.1687
0.9608 0.1304
2.6938 0.1090
10
14
32 nM Bradykinin/
RWG biosensor
1.3746
þ
0.1237 0.9808
0.01125 2.24544
0.09738 1.1312
0.2792
0.030
þ
0.2746
3.0-3.4
10
14
16 nM Bradykinin/
RWG biosensor
1.5642
0.1074 1.2346
0.1254
2.2400
0.2586
0.926
0.411
0
þ
0.8956
3.0-3.4
8 nM Bradykinin/
RWG biosensor
1.8708 0.1498 1.3706 0.2794
2.7478 0.0305 1.8908 0.1843
na
na
