Biomedical Engineering Reference
In-Depth Information
(h) Investigating enzyme kinetics using nanofluidic devices (
Goluch et al., 2009
).
(i) Single-molecule aptamer-target interactions for sensor applications (Zhang et al., 2009).
(j) Antibody-conjugated gold nanoclusters (nanoroses) for targeted cancer cellular imaging
and therapy (
Ma et al., 2009
).
(k) Combining aptamer technique with nanotechnology for ultrasensitive small molecule
and protein detection (Zhou et al., 2009).
(l) Electrochemical biosensor with self-assembled peptide nanotubes encapsulated horse-
radish peroxidase (
Park et al., 2009
).
(m) Bimimetic fabrication of optical nanobiosensor for hydrogen peroxide detection (
Tian
and Dale, 2009
).
(n) Gold nanoparticle assays: towards sensitive detection of unamplified DNA (
Verdold
et al., 2009
).
(o) Carbon nanoparticles as signal labels in protein microarrays (
van Amerongen et al.,
2009
).
(p) Streptavidin conjugated Fe
2
O
3
magnetic nanoparticles for
in-situ
biomedical applications
(
Chomuchka et al., 2009
).
(q) Nanostructured silicon-based biosensors for the determination of some mycotoxins
(
Starodub et al., 2009
).
(r) Conductive polyaniline (PANI) nanostructures for sensing applications (
Berti et al., 2009
).
(s) Gold nanoparticles nanostructured electrochemical biosensors for applications in the
food industry (
Gonzalez-Cortes et al., 2009
).
(t) Glucose biosensors based on novel carbon nanotube fiber microelectrode (
Zhu et al.,
2009
).
(u) Electrochemical immunoassay for cardiac markers as a solid phase and silver
nanoparticles as an electroactive label (
Szymanski and Porter, 2009
).
(v) Carbon nanotube electrode for biosensors (
Razumiene et al., 2009
).
(w) Antibody immobilization on gold and silver nanoparticles for use in electrochemical
immunoassays (
Szymanski et al., 2009
).
5.2 Optical DNA Detection by Multifunctional Cross-Linked
Au Nanoaggregates (
Li et al., 2009
)
Li et al. (2009)
have recently used multifunctional cross-linked Au nanoaggregates to
develop an optical DNA detection biosensor. These authors report that oligonucleotide
bridged Au (gold) nanoparticles (Au NPs) aggregate provide a red-to-blue color change
(
Elghanian et al., 1997; Mucic et al., 1998; Storhoff et al., 2000; Jiang et al., 2005
).
Rosi
and Mirkin (2005)
initially suggested that this may be used as a DNA detection agent. Since
then
Li et al. (2009)
have reported that Au NP-based or DNA detection assays have been devel-
oped (
Mirkin et al., 1996
;
Storhoff et al., 1998
;
Patolsky et al., 2000; Reynolds et al., 2000;
