Molecular Recognition of Oligopeptides and Protein Surfaces - Designing Receptors for the Next Generation of Biosensors - page 78

O

O

NH NH

R 1

O

NH

R 2 O

O

R 2

NH

O

NH HN

O

R 1

NH

R 2

O O

O O

HN

HN O

O

H

H

O

HN

HN

NH

N

R 1

O

HN O O

O

N HN

NH

O

NH

O

HN

R 2

O

O

R 1 = R 2 = ( S )-CH 2 CO 2

O O O

O

36

Fig. 11 Calix[4]arene-based, negatively charged tetravalent 36 protein surface ligand

O O

O O

O O

O

O

O HO

O O

O

O

O O

O O

O HO

O

O

O O

O

O

O

HN

H
N

O

O

O

O O

O O

O

O N

O O

N

O

O

O O

O O

O O

O O

O O

O

O

O

O O

O

N

N
H

N
S

O

O O O

O

37

O O

N

O

O

O

O

O O

O O

O O

Fig. 12 Cyclophane-based, negatively charged trivalent resorcinol-derivative 37 for the recogni-
tion of positively charged protein surfaces