Biomedical Engineering Reference
In-Depth Information
MIP NPs are particularly encouraging. A number of interesting practical appli-
cations for such materials were described and discussed in the present review. The
process of replacing natural antibodies with their synthetic analogues, however, is
hindered by the lack of suitable low costs protocols for large-scale manufacturing of
such materials. Following further advances in polymer and synthetic chemistry, as
well as in screening tools, this situation is set to change; motivating companies to
put more investment into the development of novel synthetic receptors, thus leading
to a new generation of superior affinity materials, readily available for routine
diagnostic and industrial applications.
References
1. Yan M (2002) Molecularly imprinted polymers as antibody mimics: applications in
immunoassays and recent developments. J Clin Ligand Assay 25:234-236
2. RNCOS (2011) Global in vitro diagnostic market analysis. 1-130. Rncos.com, Noida, India
3. Biocompare Surveys and Reports (2009) 2009 Antibody report - Market overview and
industry survey - Executive summary. 1-32. Market Research.com, Rockville, USA
4. Espicom (2011) Point of care diagnostics: players, products & future market prospects.
1-396. Espicom, Chichester, UK
5. Hoshino Y, Shea KJ (2011) The evolution of plastic antibodies. J Mater Chem 21:3517-3521
6. Ruigrok VJB, Levisson M, Eppink MHM et al (2011) Alternative affinity tools: more
attractive than antibodies? Biochem J 436:1-13
7. Lavignac N, Allender CJ, Brain KR (2004) Current status of molecularly imprinted polymers
as alternatives to antibodies in sorbent assays. Anal Chim Acta 510:139-145
8. Shukla AA, Th
ommes J (2010) Recent advances in large-scale production of monoclonal
antibodies and related proteins. Trends Biotechnol 28:253-261
9. Ansell RJ (2004) Molecularly imprinted polymers in pseudoimmunoassay. J Chromatogr B
Anal Technol Biomed Life Sci 804:151-165
10. Roque ACA, Lowe CR, Taipa M ˆ (2004) Antibodies and genetically engineered related
molecules: production and purification. Biotechnol Prog 20:639-654
11. Steinmeyer DE, McCormick EL (2008) The art of antibody process development. Drug
Discov Today 13:613-618
12. Urraca JL, Moreno-Bondi MC, Orellana G et al (2007) Molecularly imprinted polymers as
antibody mimics in automated on-line fluorescent competitive assays. Anal Chem
79:4915-4923
13. Haupt K, Dzgoev A, Mosbach K (1998) Assay system for the herbicide 2,4-
dichlorophenoxyacetic acid using a molecularly imprinted polymer as an artificial recogni-
tion element. Anal Chem 70:628-631
14. Szenczi A, Kardos J, Medgyesi GA et al (2006) The effect of solvent environment on the
conformation and stability of human polyclonal IgG in solution. Biologicals 34:5-14
15. Piletsky SA, Turner A (2006) A new generation of chemical sensors based on MIPs.
In: Piletsky SA, Turner A (eds) Molecular imprinting of polymers. Eurekah.com/Landes
Bioscience, Georgetown
16. Ahrer K, Buchacher A, Iberer G et al (2006) Thermodynamic stability and formation of
aggregates of human immunoglobulin G characterised by differential scanning calorimetry
and dynamic light scattering. J Biochem Biophys Methods 66:73-86
17. Omersel J, ˇ ager U, Kveder T et al (2010) Alteration of antibody specificity during isolation
and storage. J Immunoassay Immunochem 31:45-59
Search WWH ::




Custom Search