Biomedical Engineering Reference
In-Depth Information
Different from most literatures, in which dry ceramic powders were used to prepare composite
fibers, Teng et al.
[107]
explored to mix gel-like calcium phosphate precipitate directly with collagen/
hexafluoropropane (HFP) solution. The wet HA precipitate made a good blending with collagen/HFP
solution, which could stand up for several days. The uniform composite sol with 30 wt% HA had
been successfully obtained by this modified method.
Grafting PLA onto HA nanoparticles can also help the inorganic powders dispersing easily in
PLA matrix
[108]
. The electrospun composite fibers showed improved tensile strength and tensile
modulus due to the uniform distribution of PLA-
g
-HAP in the composite fibers and the relative good
interaction and adhesion between the fillers and the PLA matrix.
These calcium phosphate nanoparticle loaded polymeric fibers showed good biomineralization
behavior by being immersed in simulated body fluid and have potential use as bone scaffolds and
GTR/GBR applications.
10.4
GTR MEMBRANES BASED ON ELECTROSPUN CNT/HA
NANOPARTICLES INCORPORATED COMPOSITE NANOFIBERS
A new type of GTR membrane was developed in our lab and was described in detail in the followed
section. Electrospinning had been applied to fabricate this novel composite fibrous network con-
sisting of PLLA, MWCNTs, and HA (PLLA/MWCNTs/HA). In brief, the CNT/HA nanoparticles
were first prepared by depositing HA particles onto CNT, followed by being dispersed into PLLA/
dichloromethane solution and electrospun (
Figure 10.1
). Histologic examinations showed that PDLCs
attached on the membranes functioned well
in vivo
, while the growth of GECs was prohibited on
FIGURE 10.1
TEM observation of HA nanoparticles.
