Biomedical Engineering Reference
In-Depth Information
SHED seem to be a suitable tool for soft tissue regeneration, such as dental pulp, whereas DPSC
might be useful for engineering mineralized tissues like dentin [97] . Further development and
successful application of these strategies to regenerate dentin and dental pulp could one day revolu-
tionize the treatment of our most common oral health problem and cavities.
20.5 Conclusions
Despite the challenges in dental tissue regeneration that lie ahead, significant evidence exists to
support the premise that recent advances in nanotechnology, acting as biomimetic tools, show great
potential to overcome the challenges and promise for improved the dental tissue regeneration.
Nanomaterials tailored for engineering dental tissues are continually being introduced and yield
numerous clinical dental benefits. These include improved treatments for periodontal defects,
enhanced maxillary and mandibular bone regeneration, perhaps more biological methods to repair
teeth after carious damage and possibly even regrowing lost teeth. In the near future, advances in
bioengineering research will lead to the wide application of the regenerative dentistry into general
dental practice to produce wonderful treatments and dramatically improve patients' quality of life.
References
[1] R. Langer, J.P. Vacanti, Tissue engineering, Science 260 (1993) 920 926.
[2] S. Yildirim, S.Y. Fu, K. Kim, H. Zhou, C.H. Lee, A. Li, et al., Tooth regeneration: a revolution in
stomatology and evolution in regenerative medicine, Int. J. Oral Sci. 3 (2011) 107 116.
[3] R.W. Siegel, G.E. Fougere, Mechanical properties of nanophase metals, Nanostruct. Mater. 6 (1995)
205.
[4] S.M. Warren, K.D. Fong, C.M. Chen, E.G. Loboa, C.M. Cowan, H.P. Lorenz, et al., Tools and techniques
for craniofacial tissue engineering, Tissue Eng. 9 (2003) 187 200.
[5] L.J. Zhang, T.J. Webster, Nanotechnology and nanomaterials: promises for improved tissue regeneration,
Nano Today 4 (2009) 66 80.
[6] H. Yoshimoto, Y. Shin, H. Terai, J. Vacanti., A biodegradable nanofiber scaffold by electrospinning and
its potential for bone tissue engineering, Biomaterials 24 (2003) 2077 2082.
[7] M. Jose, V. Thomas, Y. Xu, S. Bellis, E. Nyairo, D. Dean, Aligned bioactive multi-component nano-
fibrous nanocomposite scaffolds for bone tissue engineering, Macromol. Biosci. 10 (2010) 433 444.
[8] A. Asran, S. Henning, G. Michler, Polyvinyl alcohol-collagen-hydroxyapatite biocomposite nanofibrous
scaffold: mimicking the key features of natural bone at
the nanoscale level, Polymer 51 (2010)
868 876.
[9] J. Venugopal, M. Prabhakaran, Y. Zhang, S. Low, A.S. Choon, S. Ramakrishna, Biomimetic
hydroxyapatite-containing composite nanofibrous substrates for bone tissue engineering, Philos Transact.
A Math Phys. Eng. Sci. 368 (2010) 2065 2081.
[10] M.J. Gupte, P.X. Ma, Nanofibrous scaffolds for dental and craniofacial applications, J. Dent. Res. 91
(2012) 227 234.
[11] T.J. Webster, C. Ergun, R.H. Doremus, R.W. Siegel, R. Bizios, Specific proteins mediate enhanced
osteoblast adhesion on nanophase ceramics, J. Biomed. Mater. Res. 51 (2000) 475 483.
[12] T.J. Webster, C. Ergun, R.H. Doremus, R.W. Seigel, R. Bizios, Enhanced osteoclast-like cell functions
on nanophase ceramics, Biomaterials 22 (2001) 1327 1333.
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