Biomedical Engineering Reference
In-Depth Information
TABLE 10.2 (CONTINUED)
Nano/Microibrous.Textures.Used.for.Nerve.Tissue.Engineering
Polymer
Concentration/
Composition/Solvent
InVitro
Studies:
CellType
InVivo
Studies:
NerveInjuryModel
PolymerType
FiberDiameter
Reference
PLLA
3.w/w%
CHL
524.±.305.nm.(RF/AF)
Dorsal.root.ganglia.
explant
—
Corey.et.al.,.2007
PLLA
1%.w/w
3%.w/w
2%.w/w
5%.w/w
DCM:DMF.70:30,.v:v
250.nm.(RF)
1.25.µm.(RF)
300.nm.(AF)
1.5.µm.(AF)
Neonatal.mouse.
cerebellum.C17.2.stem.
cells
—
Yang.et.al.,.2005
Ekaputa.et.al.,.2008
PLLA
8%.w/w
CHL
1.2-1.6.μm.(AF)
Embryonic.(E9).chick.
dorsal.root.ganglia.
explants.and.rat.
Schwann.cells
—
Wang.et.al.,.2009
PLLA/.PLGA
10%.w/v
THF.and.DMF
510.±.380.nm.(PLLA,.RF)
760.±.300.nm.(PLGA,.RF)
Mouse.embryonic.
cortical.neurons
—
Nisbet.et.al.,.2007
PLGA,.75/25.(coated.
with.polypyrrole)
6.5%.w/w.(RF)
7.0%.w/w.(AF)
HFIP
520.±.150.nm.(RF)
430.±.180.nm.(AF)
(85.±.41.nm.shell.thickness)
PC12.cells.and.rat.
embryonic.hippocampal.
neurons
—
Lee.et.al.,.2009
Poly(ε-caprolactone-
co-ethyl.ethylene.
phosphate).(PCLEEP)
12%.w/w
DCM
5.08.±.0.05.μm.(AF)
—
15.mm.nerve.lesion.gap.in.
rat.sciatic.nerve.(cell-free)
Chew.et.al.,.2007
Blend.of.PLGA.75:25/
PCL
5.5%.w/w.PCL:
4%.w/w.PLGA
CHL:MeOH.3:1
279.±.87.nm.(RF)
—
10.mm.nerve.gap.in.rat.
sciatic.nerve.(cell-free)
Panseri.et.al.,.2008
FibersFabricatedby
Self-Assembly
RAD16-I*.(Arg-Ala-
Asp).and.RAD16-II**
Cell.culture.media
10-20.nm
Rat.PC12.cells.
Mouse.hippocampal.and.
cerebellar.granule.
neurons
Rat.hippocampal.
neurons
Injection.of.self-assembled.
(20.µl).in.rat.right.leg.
(cell-free)
Holmes.et.al.,.2000
