Biomedical Engineering Reference
In-Depth Information
Table 8.1
Summary of available products used as cell carriers
Product
Manufacturer
Properties of product
Reference
Biobrane
Smith & Nephew
Nylon fabric embedded
35, 46
in silicone film coated
with collagen 1
Alloderm
LifeCell
Acellular dermal matrix
22, 47, 48
sourced from human
tissue may be preseeded
with fibroblasts
LaserSkin
Fidia Advanced
Benzyl esterified hyaluronic 49, 50, 51
Biopolymers
acid with laser drilled
holes may be co-seeded
with fibroblasts
Myskin
CellTran
Silicone coated with
37, 52
plasma polymer film
Chitosan
Experimental chitosan
Chitosan with lamanin
53, 54
is available from a
peptide AG73
number of sources
Epigen
Smith & Nephew
Polymeric film of
32, 55, 56
ethylene vinyl acetate
and polystyrene
Tegaderm
3M
Polyurethane
57, 58
Hydroderm
Innovative Technologies
Polyurethane
38, 59
Tisseel
Baxter
Allograft plasma and
22, 41, 42
bovine thrombin
•
be non-allogenic
•
allow keratinocyte migration onto the wound
•
be flexible to allow contouring to the wound surface
•
be shed/degraded as the epithelial surface matures.
Many carriers have been reported in the literature, the composition ranges from
synthetic polymers to biological fibrin mats, AG73 chitosan, Alloderm, to combi-
nations such as Biobrane with collagen and silicone. Table 8.1 indicates the
literature published in the area of pre-confluent cell delivery using carrier systems
which are available. Work has been reported using microcarriers of absorbable
synthetic material which have not been widely used clinically owing to the
associated inflammatory response.
39
The cell seeding density varies with the timing of seeding and of clinical use.
Various clinical cases are reported in acute and chronic wounds and all report
enhanced epithelial repair.
8.5
Summary
With the exploration of the clinical indications for the use of cells harvested from
