Biomedical Engineering Reference
In-Depth Information
ATMI Life Science's Nucleo single-use bioreactors have a cube-shaped
bag instead of a cylindrical bag, a tumbling (Pad-Drive) mixing system
instead of a rotating impeller, and a dynamic sparging arrangement in
place of a static structure and is available in 50 L and 1,000 L volumes
(ATMI
http://www.atmi-lifesciences.com
)
.
Integrity™ PadReactor™
The Integrity™ PadReactor™ system is a single-use bioreactor specifically
designed to fulfill the needs of cell culturists. It is perfectly suited to labo-
ratory environments, process development centers, clinical material supply,
and flexible GMP manufacturing. The PadReactor offers an open architec-
ture controller platform, which gives the end-user the opportunity to choose
a preferred controller or use an existing control system.
The bioreactor vessel, which offers comparable functionality to classical
stirred-tank bioreactors, is a single-use bag integrating an internal paddle
mixing and sparger system. This innovative bag design allows a noninvasive
connection to the system. The paddle is enclosed in a medical-grade ultra
low density polyethylene (ULDPE) sleeve made from the same contact mate-
rial as the bag itself, and is coupled on top of the vessel with the mechanical
mixing head.
As with all ATMI LifeSciences' single-use systems, the Integrity PadReactor
utilizes disposable mixing bags made from TK8 bioprocess film. The prod-
uct-contacting layer of TK8 film is blow-extruded in-house by ATMI under
cleanroom conditions using medical-grade ultralow-density polyethylene
resin. It is then laminated to create a gas barrier film of exceptional cleanli-
ness, strength, and clarity that is animal-derived component free (ADCF)
and complies fully with USP Class VI requirements.
The Integrity PadReactor single-use bioreactor consists of the following:
Drive unit: The flexible drive unit allows the system to cultivate cells in
disposable bags. One drive unit can allow the user to mix in multiple
disposable mixing bags of various sizes. Each system comes with the
appropriate mixing stick for your container.
Mobile retaining tank: The purpose of the retaining tank is to support
the mixing bag and provide mobility before and after the operation.
Various tank sizes and options are available.
Bioreactor vessel: The reactor vessel uses an innovative bag design that
allows a noninvasive connection to the mixer. Mixing is achieved
when the integrated paddle/sparger inside the bag rotates within
the bag.
