Biology Reference
In-Depth Information
JH
Cycle
TAIMAN
Met
nucleus
Cycle
TAIMAN
kr-h1
;
hairy
Met
JH-RE/E-box
Figure 1.5 The JH receptor, Methoprene-tolerant (Met) interacts with CYCLE and
Taiman (aka FISC or SRC), which are, like Met, members of the bHLH-PAS protein family
(
Kewley, Whitelaw, & Chapman-Smith, 2004; Li et al., 2011
). These proteins form a func-
tional complex in fat body cells following JH signaling during mosquito oocyte
development.
understanding of strictly timed processes that govern insect development.
It is becoming increasingly clear that the circadian machinery plays a pivotal
role in regulating many of the key developmental events that drive the
remarkable transformation of an egg into a complex adult. This notion is
not just restricted to insect development but similar concepts have been
unearthed in
C. elegans
(
Banerjee, Kwok, Lin, & Slack, 2005
), zebrafish
(
Dekens et al., 2003
), and in mammals
(
Kennaway, 2005; Pilorz &
Steinlechner, 2008
).
However, the idea that peripheral clocks dictate the timing, at least in
part, of developmentally active hormones and their corresponding respon-
ses has gained some considerable traction, but more research is required
to understand how endocrine systems interact with peripheral and central
clocks. Specifically, a systematic disruption of circadian rhythm genes in
