Biology Reference
In-Depth Information
CHAPTER FOUR
MicroRNAs as Components
of Systemic Signaling Pathways
in Drosophila melanogaster
Department of Biology, Indiana University, Bloomington, Indiana, USA
1
Co-first authors.
2
Corresponding author: e-mail address: nsokol@indiana.edu
Contents
1.
Introduction
98
2. Overview of miRNA Biogenesis and Function
99
3.
Insulin and Nutritional Pathways
99
3.1 Overview of ILPs and insulin signaling
100
3.2 Identification of miRNAs involved in insulin signaling
102
3.3 miR-14
102
3.4 miR-278
102
3.5 miR-8
102
3.6 miR-33
103
3.7 dcr-1
103
3.8 miR-1
104
4. Lipophilic Hormone Signaling Pathways
104
4.1 Overview of Ecdysone and JH signaling pathway
104
4.2 Identification of Ecdysone- and JH-regulated miRNAs
106
4.3 Molecular analysis of Ecdysone- and JH-control of let-7-C, miR-34, miR-8,
and miR-14 miRNAs
107
4.4 Biological roles of Ecdysone regulated let-7-C miRNAs
108
4.5 miR-14 and miR-8: molecular links between steroid and insulin signaling
pathways
111
4.6 miR-34
112
5. Light Modulated Circadian Rhythm Pathways
113
5.1 Molecular overview of circadian rhythm pathway
113
5.2 Identification of miRNAs in clock pathways
114
5.3 bantam
114
5.4 miR-279
115
5.5 miR-959
-
964 cluster
116
6. Stress Induced and Immune Response Pathways
116
