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development cost, which however introduced two major problems, i.e., dependence
on the Miceosoft's future strategy on Silverlight and poor cross platform
compatibility. In 2013, we have started to develop a new HTML5 based
WebbleWorld system which will become available soon.
Figure 12 shows the architectural features of WebbleWorld. It is a Web-top meme
media system. Composite pads or webbles run in a Web page. Therefore, the
extracting and the wrapping of a Web application function can be done inside the
Web without even temporarily going outside the Web. Therefore, we call this
extension the memetic Web.
proxy pads
Web
service A
reediting &
redistribution
Web
service B
The Web
clipping
RIA (Silverlight) tech.
copy
publish
The Memetic Web
Only requires Silverlight-empowered browser!
reuse in local
environments
Fig. 12.
The architectural features of WebbleWorld
7
Application to the Integrated Support of Clinical Trial
on Cancer
In the ACGT project from February 2006 to July 2010, we developed TOB (Trial
Outline Builder) jointly with Norbert Graf, the Director of the Clinic for Pediatric
Oncology and Hematology at Saarland University [20]. TOB is an integrated visual
environment for (1) designing the CRF (Case Report Form) of each therapeutic event,
(2) designing a trial master plan as a flow diagram by copy-and-pasting each event to
draw a flow diagram, (3) using a single path in the flow diagram to guide both the
treatment of a specific patient and the data input to the CRF of each event, and (4)
supporting visual analytics of accumulated patient data after the completion of the trial.
Figure 13 shows these second, third, and fourth stages of TOB system. The trial master
plan starts with the stratification which corresponds to the registration of each patient
to the trial and the dispatch of the patient to an appropriate treatment path depending
on his or her case. Each treatment path is a sequence of different types of therapeutic
events like radio therapy events, chemotherapy events and surgery events. Each path
may have diagnostic events at some points of the flow. Some treatment path may have
a randomization followed by more than one treatment branch. Each patient dispatched
