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to such a path is randomly dispatched to one of the branches called treatment arms
after the randomization. A trial master plan also has some number of adverse events
outside its whole flow. These correspond to the treatment events conducted by
clinicians at some emergency by neglecting the planned flow. One of the main
purposes of the visual analytics with TOB, for example, is to find out specific patient
cases for which some treatment arm after the randomization may show better survival
rate than other arms. In order for analysts to find out such cases, the visual analytics
stage of TOB provides a parallel coordinate system with various visualizations of trial
data including the life table. Each coordinate in the parallel coordinate system
represents an entity of the CRF of some treatment event in the master trial plan. Each
polygonal line in such a parallel coordinate system represents an individual patient.
Each coordinate allows us to select only those patients whose value of the
corresponding entity falls between two arbitrarily specified boundaries. Users can
specify more than one pair of such boundaries in each coordinate. Suppose that an
exploratory filtering of patients in the parallel coordinate system results in a life table
visualization in which one treatment arm after the randomization shows better survival
rate than others. Then we may conclude that this treatment arm should be chosen for
those patients currently selected by the parallel coordinate system. This leads to the so-
called personalized medicine. Our knowledge federation framework based on the
meme media architecture enabled us to rapidly develop TOB which accesses the trial
data stored in the ObTiMA database developed by Fraunhofer IBMT. We easily
wrapped ObTiMA database into a pad. Since the WebbleWold is a Web top meme
media system, TOB was easily embedded in the Web portal of ObTiMA.
Fig. 13.
TOB showing its second, third, and fourth stages
The improvisational knowledge federation capability of the meme media architecture
also enabled us to easily extend TOB by bringing in the reference to patient genomic
data and DICOM image files. Figure 14 shows the heatmap visualization of gene
