Biomedical Engineering Reference
In-Depth Information
atherosclerosis using Raman spectroscopy [
102
,
103
]. Raman spectroscopy has also
been used for bone diagnosis [
104
], brain tumor diagnosis [
105
], prostate cancer
diagnosis, and bladder malignancy diagnosis [
106
-
108
].
1.5
Summary
In summary, we discussed the basic components and their advancement for the
standard spectroscopy system and the design of
in vivo
Raman spectroscopy systems
and their biomedical applications. We have focused on the
in vivo
Raman system
design. Other modalities of Raman spectroscopy such as coherent anti-Stokes
Raman spectroscopy (CARS) [
109
], surface-enhanced Raman spectroscopy [
110
],
and time-resolved Raman spectroscopy [
111
] are not discussed as those are mostly
ex vivo
diagnosis methods.
The advancement of technology provides researchers the opportunity to push the
applications of biomedical spectroscopy into new horizons. Because the signal is
relatively strong, diffuse reflectance and fluorescence spectroscopy or imaging will
continue to find their way as diagnostic or visual aid tools in biomedicine. As an
emerging
in vivo
technique, we expect
in vivo
Raman spectroscopy will become a
powerful clinical tool in the years to come.
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