Biology Reference
In-Depth Information
Table 10.1
Summary of Interactions between Viruses and LDs
Implicated Step in
Infection
Virus
Virus Family
Interactions Between Virus and LDs
References
Hepatitis C
virus
Flaviridae ss, (
þ
)
Virions circulate as lipoviroparticles
Infectious virion
(
Andre et al., 2002; Nielsen et al.,
2006, 2008; Thomssen et al., 1992
)
RNA
Viral entry requires low-density
lipoprotein receptors
Entry
(
Sabahi, 2009
)
Membranous vesicles required for RNA
replication contain lipid rafts NS5A
interacts with TIP47
RNA replication
(
Aizaki, Lee, Sung, Ishiko, & Lai,
2004; Shi, Lee, Aizaki, Hwang, &
Lai, 2003; Vogt et al., 2013
)
Core and NS5A translocate to LDs via
DGAT1
Assembly
(
Camus et al., 2013; Herker et al.,
2010)
Virions use the low-density lipoprotein
secretion pathway for release
Virion release
(
Chang, Jiang, Cai, & Luo, 2007;
Gastaminza et al., 2008; Huang
et al., 2007
)
Core expression induces steatosis
(
Clement et al., 2011; Moriya et al.,
1997, 1998
)
Dengue virus
Flaviridae ss, (þ)
RNA
Capsid protein colocalizes with LDs
Assembly
(
Carvalho et al., 2012; Samsa et al.,
2009
)
Viral infection causes increase in LDs
Assembly
(
Samsa et al., 2009
)
Viral infection causes autophagy-
dependent depletion of LDs
RNA replication
(
Heaton & Randall, 2010, 2011
)
NS3 protein recruits FASN to sites of
RNA replication
RNA replication
(
Heaton et al., 2010
)
Rotavirus
Reoviridae ds,
RNA
Inclusion bodies (viroplasms) colocalize
with perilipin and ADRP
RNA replication,
viroplasm formation,
cell death
(
Cheung et al., 2010
)
Orthoreovirus
Reoviridae ds,
RNA
m1 protein colocalizes with LDs
LDs as a protein-
storage depot
(
Li et al., 2012
)
Hepatitis B
virus
Hepadnavirus
partial ds, DNA
HBx expression causes lipid
accumulation
Transcription
(
Kim, Kim, Kim, & Cheong, 2008;
Kim et al., 2007; Na et al., 2009
)
ss, single-standed; ds, double-stranded; (
þ
), positive-sense, FASN, fatty acid synthase.
