Biology Reference
In-Depth Information
Number of
genes on
chip
Number of
differentially
expressed genes
Regenerating
cell/injury
Control cell/
injury
Time
postinjury
Species
Threshold
CNS development
Profiling method
Mechaly et al. (2006)
SAGE library
NA
Mouse DRG/sciatic
nerve transection
Uninjured
DRG
3 days
N/A
1415 (566
known)
Stam et al. (2007)
Agilent
Microarray
8.1K
8099
Rat
DRG/sciatic
nerve crush
DRG/dorsal
root crush
6, 12, 24 h,
2, 3, 7, 14
days
Limma
statistics with
5% FDR
426
Zou, Ho, Wong, and
Tessier-Lavigne
(2009)
Microarray
?
Mouse DRG/sciatic
nerve transection
DRG/spinal
cord
transection
12 h, 24 h
?
133 (12 h),
429 (24 h)
Smith et al. (2011)
Subtractive
cDNA library
construction
NA
Mouse Cultured DRGs Whole
cerebellum
3 days
N/A
1068
Michaelevski et al.
(2010)
Microarray
(Affymetrix
230.2)
31,000
Rat
DRG/sciatic
nerve crush
Uninjured
DRG
1, 3, 8, 12,
18, 24, 28 h
Statistical
2700
Zebrafish retina
Veldman et al. (2007)
Microarray
(Affymetrix)
14,900
Zebrafish LCM-captured
RGCs/optic
nerve crush
Uninjured
RGCs
3 days
1.8-fold
change,
P
347 upregulated
>
0.05
<
McCurley and
Callard (2010)
Microarray
(Affymetrix)
14,900
Zebrafish Whole retina/
optic nerve crush
Uninjured
retina
6h,1,4,12,
21 days
2-fold
change
1000
>
>
Saul et al. (2010)
Microarray
(Zebrafish
OciChip)
14,000
Zebrafish Whole retina/
optic nerve crush
Uninjured
retina
3 h, 1, 7 days
2-fold
change
120
>
