Theoretical Models of Immune Processes - Immunological Computation: Theory and Applications - page 43

9. Illustrate with a diagram, a multiepitope IN approach as a PDP with input or
output and hidden layers.
10. Mention two diff erent models of the GC? Explain how they diff er.
11. Why is somatic hypermutation necessary during the B cell a nity matura-
tion process?
12. Explain the main ideas of DT and the integrity model.
13. Explain the four diff erent stimuli categories proposed in DT.
14. Mention the computational features of adaptive immune systems.
15. Try to formulate some computational aspects of the immune system diff erent
from the ones explained in this chapter.
References
Berek, C., A. Berger and M. Apel. Maturation of immune response in germinal centers.
Cell, 67, 1121-1129, 1991.
Bersini, H. Self-asssertion vs self-recognition: A tribute to Francisco Varela. Proceedings of
the fi rst ICARIS conference, Canterbury, pp. 107-112, 2002.
Bretscher, P. and M. Cohn. A theory of self-nonself discrimination. Science, 169(3950),
1042-1049, 1970.
Burnet, F. M. h e Clonal Selection h eory of Immunity . Cambridge University Press,
London, 1959.
Burnet, F. M. h e evolution of receptors and recognition in the immune system. In P. Cua-
trecasas and M. F. Greaves (Eds.), Receptors and Recognition , Vol. 1, Ser. A, pp. 33-58,
Chapman & Hall, London, 1976.
Camacho, S. A., M. H. kosco-Vilbois and C. Berek. h e dynamic structure of the germinal
center. Immunol. Today , 19, 511-514, 1998.
Casamayor-Palleja, M., A. Gulbranson-Judge and I. C. M. MacLennan. T cells in the
selection of germinal center B cells. In M. Ferrarini and F. Caligaris-Cappio (Eds.),
Human B Cell Populations. Chemical Immunology. Karger, Basel, Vol. 67, pp. 27-44,
1997.
Celada, F. and P. E. Seiden. A nity maturation and hypermutation in a simulation of the
humoral immune response. Eur. J. Immunol. , 26, 1350-1358, 1996.
Coutinho, A. Beyond clonal selection and network. Immunol Rev ., 110 (Aug), 63-87,
1989.
Dasgupta, D. (Ed.) Artifi cial Immune Systems and h eir Applications . Springer, Berlin, 1999.
De Boer, R. J. Clonal Section Versus Idiotypic Network Models of the Immune System: A Bioin-
formatics Approach . PhD thesis, University of Utrecht, the Netherlands, 1989.
Dembic, Z. Immune system protects integrity of tissues. Mol. Immunol ., 37(563), 8, 2000.
Hightower, R. Computational Aspect of Antibody Gene Families . Dissertation, Technical
Report, h e University of New Mexico, Albuquerque, NM, 1996.
Hoff mann, G. W. A theory of regulation and self-nonself discrimination in an immune
network. Eur. J. Immunol., 5(9), 638, 1975.
Jacob, J., G. Kelsoe, K. Rajesky and U. Weiss. Intraclonal generation of antibody mutants
in germinal centers. Nature, 354, 389-392, 1991.