Immunology Basics - Immunological Computation: Theory and Applications - page 24

25. What are the roles of MHC molecules in recognizing antigenic peptides?
26. Which are the mechanisms that defi ne the immune system's dynamical
behavior?
27. Why does the immune system react in a stronger and faster fashion when it
is exposed to an antigen for a second time?
28. Explain the functional diff erences between ABRs in T and B cells during
maturation.
29. Explain positive and negative selection during T cell maturation.
30. Order the following list of processes with respect to their temporal occur-
rence in B cell activation. Explain each process.

• An antibody on the surface of a B cell binds to an antigen.

• Clonal selection

• Antibodies become either memory cells or plasma cells

• Somatic hypermutation

• A nity maturation

• Production of a pool of antibody-secreting plasma cells and memory cells

31. How is the circulatory system involved in immune response?
32. Do humoral and cellular immunity follow a similar sequence of defense
steps?
33. Explain the diff erence between immune diff usion and immune dialogue.
34. Why is signaling important in biological defense?
35. Draw a diagram showing diff erent strategies and mechanisms providing over-
all immune defense (coverage).

References
Abbas, A . K . and A . H. Lichtman. Basic Immunology: Functions and Disorders of the Immune
System , Saunders, 2004.
Abbas, A. K. and A. H. Lichtman. Cellular and Molecular Immunology , 5th Edition, Saun-
ders, 2005.
Baumann, H. and J. Gauldie. h e acute response. Immunol Today , 15(74), 74-80, 1994.
Clancy, J. Basic Concepts in Immunology: A Student's Survival Guide , McGraw-Hill, New
York, 1998.