Biomedical Engineering Reference
In-Depth Information
Table 14.4.
Receptors
of
the
parasympathetic
postganglionic
neurons
(Vol.
3
-
Chap.
7.
G-Protein-Coupled Receptors).
Type
Effect
Cardiovascular apparatus
Muscarinic M
2
GPCR
Decreased cardiac output
Attenuated cardiac frequency (negative chronotropy)
Reduced contractility (negative inotropy)
Decreased conduction (negative dromotropy)
Vascular smooth muscle relaxation
Muscarinic M
3
GPCR
Vascular smooth muscle contraction
Muscarinic M
5
GPCR
Vasodilation of cerebral arteries
Respiratory apparatus
Muscarinic M
3
GPCR
Airway smooth muscle contraction
These collaborative programs aims at boosting, on the one hand, health knowl-
edge acquisition, formalization, representation, and communication, as well as,
on the other, training to diagnostic and therapeutic procedures, identification of
relevant biomarkers to foster early diagnosis of chronic diseases and prevention,
development of drug nanovectors, optimization of treatment planning, elaboratation
of augmented reality-based image-guided interventions, optimal design of artificial
organs, and remote medical decision and gesture.
Strategies usually combine data mining, advanced data analysis techniques, non-
invasive imaging, image and signal processing, parameter identification, cell and
tissue characterization, biochemical and biophysical modeling, high-performance
computing, verification and experimental validation, and production of coupling
platforms and computer-assisted medicine softwares.
