Vascular Endothelium - Tissue Functioning and Remodeling in the Circulatory and Ventilatory Systems - page 552

Table 9.28. Coagulation factors (Source: [ 1025 ]). Hepatic-derived, vitamin K-dependent
procoagulants, i.e., coagulation factor-II (prothrombin), -VII, -IX, and -X, are substrates for the
thrombin formation by activated factor-X (Xa) in the common pathway that participates in platelet
agglutination.

Coagulation factors Targets

Number Name (alias)

I Fibrinogen (Fng) Fn

II Prothrombin I, V, VII, XIII, PC, platelets

III Tissue factor (TF) VII

Ca 2 +

IV V, VIII, IX, X

V Proaccelerin X, II

VI Accelerin (FVa)

VII Proconvertin IX, X

VIII Antihemophilic factor-A IX, X

IX Antihemophilic factor-B X

Plasma thromboplastic component

X Stuart-Prower factor II

Prothrombin converting enzyme

XI Plasma thromboplastin antecedent XII, preKK

(PTA)

XII Hageman or contact factor XIa, preKK, Fn

XIII Fibrin-stabilizing factor Fn

XIV Protein-C (PC) V, VIII

Other clotting factors Targets

von Willebrand factor (vWF) VIII, platelet

Prekallikrein (preKk) XIIa, preKK, HMWK

High-molecular-weight kininogen (HMWK) XII, XI, preKK

Antithrombin-3 (AT or AT3; serpin-C1) IIa, Xa

Heparin cofactor-2 (serpin-D1) IIa

Protein-S (PS or PS α ) PC

Plasminogen (Png) Pn, Fn

α 2-Antiplasmin (serpin-F2) Pn

Prourokinase (proUK) Png

Tissue plasminogen activator (tPA) Png

Plasminogen activator inhibitor
PAI1 (serpin-E1)

Png, tPA

PAI2 Urokinase

9.8.1.1 Primary Hemostasis

Primary hemostasis refers to the plug formed by platelets that aggregate at injury
site to seal damaged blood vessels and stop bleeding. Blood vessel injury at a more
or less high blood pressure site according to the vasculature locus exposes collagen
and tissue factor and triggers blood coagulation and thrombocyte activation, accu-
mulation, and aggregation.