Vascular Endothelium - Tissue Functioning and Remodeling in the Circulatory and Ventilatory Systems - page 506

Table 9.18. Endothelial cells are able to synthesize multiple growth factors (Source: [ 928 ]).
( Part 5 ) Cytokines, chemokines, and adipokines (CT1R: cardiotrophin-1 receptor; CNTFR: ciliary
neurotrophic factor receptor; LIF: leukemia inhibitory factor). Cardiotrophin-1 (CT1), a member of
the IL6 family, is a cytokine capable of inducing cardiomyocyte hypertrophy. Ciliary neurotrophic
factor (CNTF) is a cytokine that assists in the differentiation and survival of various cell types in the
peripheral and central nervous systems. A secreted complex made of cardiotrophin-like cytokine
(CLC) and cytokine-like factor-1 (CLF), like CNTF, acts via CNTF receptor.

Type Receptors

Cytokines

CT1 CT1R (GP130-LIFR)

CNTF, CLC-CLF CNTFR (LIFR-CNTFR-GP130

Ifn α / β / γ IfnaR1, IfngR1

IL1-IL3, IL5-IL8, IL1RA, IL1R2, IL2R α -IL4R α ,

IL10-IL20, IL23-IL25, IL6R α -IL8R α , IL10R α -IL11R α ,

IL27-IL29, IL32-IL33, IL13R α , IL15R α , IL17Ra, IL18R,

IL36 IL20R, IL22R1, IL27R α , IL33R

LIF LIFR

Oncostatin-M receptor (OSMR)

Prolactin Prolactin receptor

TNFSF1-TNFSF7, TNFSF10-TNFSF11, TNFRSF1a-TNFRSF1b,

TNFSF13b (20), TNFSF15 TNFRSF3-TNFRSF5,

TNFRSF6b/11b/12a/14/16/21/25 (12)

Chemokines
CCL1-CCL5, CCL7-CCL8, CCL11, CCR1-CCR9

CC15-CCL24, CCL26-CCL28
CXCL1-CXCL7, CXCL9-CXCL13, CXCR3-CXCR4, CXCR6-CXCR7

CXCL16-CXCL17
CX 3 CL1 CX 3 CR1

XCL1

Adipokines
Leptin receptor
RBP4 receptor
Resistin receptor

Visfatin Visfatin receptor

On the other hand, anti-angiogenic miR221 and miR222 repress stem cell factor
receptor and endothelial nitric oxide synthase (NOS3). Moreover, miR221 and
miR222 control the synthesis of other microRNAs for more or less redundant
activity.
MicroRNA cluster miR17-92 (miR17, miR18a, miR19a-miR19b, miR20a,
and miR92a) is significantly upregulated in tumors to promote angiogenesis in a
paracrine manner [ 933 ]. These miRs target anti-angiogenic proteins. MicroRNA-18