Blood Cells - Tissue Functioning and Remodeling in the Circulatory and Ventilatory Systems - page 119

Table 3.22. Markers and transcription factors of T-lymphocyte populations ( Part 1 ;
Source: [ 225 ]; BCL6: B-cell lymphoma protein-6, a.k.a. zinc finger and BTB domain-containing
protein ZBTB27 and zinc finger protein ZNF51; BLIMP: B-lymphocyte-induced maturation
protein, a.k.a. -interferon gene positive regulatory domain I-binding factor, positive regulatory

domain I-binding factor PRDIBF1, and positive regulatory domain-containing protein-1 with
zinc finger domain PRDM1; BMI1: polycomb group RING finger proto-ongogene product, a.k.a.
protein CCR: CC-chemokine receptor; MBD: methyl-CpG-binding domain protein [demethylase];
Runx: Runt-related transcription factor; TCR: T-cell receptor; THPOK: T H -inducing POZ-
Kruppel-like factor, a.k.a. zinc finger and BTB domain-containing protein ZBTB7b [or ZBTB15]
and zinc finger protein-67 homolog ZFP67).

β

Subset Plasmalemmal markers and transcription factors

CD4 + αβ αβ TCR, CD3, IL7R, IL16R (CD4), CCR7,

L-selectin high , PTPRc (CD45); THPOK

CD8 + αβ αβ TCR, CD3, CD8, IL7R, CCR7,

L-selectin high , PTPRc, Runx3

CD8 αα αβ or γδ TCR, CD3, PTPRc,

CD8 αα ; KGF

γδ γδ TCR, CD3

Ifn γ - and IL17a-producing, TNFRSF7- and CCR6-expressing subpopulations

TCR, CD3, IL7R, IL15R, CCR7 high ,
CD44, L-selectin high ,
BCL6/6b, MBD2, BMI1 (RNF51)

Central memory

TCR, CD3, IL7R, IL15R, CCR7 low ,
CD44, L-selectin low ,BLIMP1(PRDM1)

Effector memory

hand, most of the T cells remain double-negative cells, but downregulate

expression of CD24 during maturation.
γδ

γδ

T cells give rise to at least 2 functionally distinct subsets: Ifn γ -and

IL17-producing γδ T cells. In the thymus, TNFRSF7 + γδ thymocytes express

TNFRSF3, TBx21, and Ifn γ , whereas TNFRSF7 − γδ thymocytes express ROR γ 2

(NR1f3-2) and polarize to IL17-producing γδ T cells [ 223 ].

3.10.4.1 ˛ˇ T-Lymphocyte Subsets

+
T lymphocytes recruit macrophages and neutrophils to the site of tissue damage.
CD8

αβ

Several T lymphocyte subsets exist (Tables 3.22 to 3.27 ). Inflammatory CD4

+

cytotoxic T lymphocytes (CTL) kill cells infected by viruses, bacteria, or
protozoans, allograft, and tumor cells. They have cytoplasmic granules that contain
perforin and granzymes [ 224 ]. Regulatory T lymphocytes dampen excessive inflam-
mation. Helper T cells enhance the production of antibodies by B lymphocytes.