Biology Reference
In-Depth Information
Table 4.4. Electrochemical genosensors using Au-NPs ascarriers
Analyte
Modified ElectrodeSubstrate
Detection Technique
Detection Limit
Reference
DNA synthetic strands
Silicon wafer nanogap
Current-voltagemeasurement
-
53
0.1 ng mL
−
1
Thrombin
Pyrolyticgraphite
DPV (adenine)
54
Eco
RIendonuclease
AuE
CV (ferrocene)
-
55
Chronocoulometry [Ru(NH
3
)
6
]
3
+
∼
Breast cancer-associated BRCA-1 mutant DNA
AuE
fM
56
Chronocoulometry [Ru(NH
3
)
6
]
3
+
DNA synthetic strands
NPGE
28 aM
57
Pb
2
+
AuE
DPV
1 nM
16
DNA synthetic strands, IgG
SPE
DPV
30 fM (DNA)25 fg/mL(IgG)
58
10
−
10
M
×
Adenosine
AuE
CV
1.8
59
10
−
10
M
×
Cytocrome c
AuE
CV
6.7
60
DPV (Cd
2
+
)
4.2
×
10
−
15
M
DNA synthetic strands
GCE
50
ASV (Pb
2
+
)
5.0
×
10
−
15
M
DNA synthetic strands
MFE
51
DPASV (Pb
2
+
)
6.2
×
10
−
15
M
Thrombin
AuE
61
Hg(II)
AuE
SWV
0.5 nM (100 ppt)
62
Chronocoulometry [Ru(NH
3
)
6
]
3
+
4
×
10
−
13
M
Glutathione
AuE
52
DPV [Ru(NH
3
)
6
]
3
+
1.4
×
10
−
11
M
Synthetic oligonucleotides
AuE
25
Chronocoulometry [Ru(NH
3
)
6
]
3
+
ATP
AuE
0.2 nM
63
CV [Ru(NH
3
)
5
Cl]
2
+
1
×
10
−
14
M
Platelet derivedgrowth factor
AuE
64
