Handling Copper: A Paradigm for the Mechanisms of Metal Ion Homeostasis - Environmental Contamination: Health Risks and Ecological Restoration - page 276

TABLE 13.2 (continued)
List.of.Copper.Traficking.Proteins.in.Yeast

CopperTransport-RelatedProteins
andRegulatoryElements CellularLocation Function Homologs References

Cox17.and.Cox19 Mitochondrion Incorporation.of.copper.into.

cytochrome. c .oxidase.in.
mitochondrion

Cox17.( A. thaliana ) Beers.et.al..(1997),.Nobrega.

et.al..(2002)

Cox11
Sco1

Mitochondrion
Mitochondrion

Incorporation.of.copper.into.
cytochrome. c .oxidase
Incorporation.of.copper.into.
cytochrome. c .oxidase

Horng.et.al..(2004),.Hiser.
et.al..(2000),.Nittis.et.al..
(2001),.Winge.(2003),.
Beers.et.al..(2002)

Targets.for.Cu(I)
Fet3

Extracellular Multi-copper.ferroxidase/iron.

permease;.high.afinity.iron.
uptake

Dancis.et.al..(1994),.Askwith.
et.al..(1996),.Yuan.et.al..
(1995),.De.Silva.(1995)

SOD1 Cytoplasm Enzyme.that.reduces.reactive.

oxidative.stress

CSD1.( A. thaliana )

Cco Mitochondrion Terminal.electron.acceptor.in.

respiration

Transcriptional.Regulation
Mac1 Nucleus Transcriptional.activation.of. FRE1,

CTR1, CTR3

Georgatsou.et.al..(1997),.
Labbe.et.al..(1997),.
Yamaguchi-Iwai.et.al..
(1997),.Zhu.et.al..(1998)

Ace1 Nucleus Transcriptional.activation.of.

SOD1, CRS5, CUP1

Culotta.et.al..(1994),.Thiele.
(1988),.Gralla.et.al..(1991)

Metallothionein
Crs5
Cup1

Cytoplasm
Cytoplasm

Sequesters.excess.copper
Sequesters.excess.copper

Culotta.et.al..(1994)
Karin.et.al..(1984)