Handling Copper: A Paradigm for the Mechanisms of Metal Ion Homeostasis - Environmental Contamination: Health Risks and Ecological Restoration - page 275

TABLE 13.2
List.of.Copper.Traficking.Proteins.in.Yeast

CopperTransport-RelatedProteins
andRegulatoryElements CellularLocation Function Homologs References

Yeast
Saccharomyces cerevisae
Reductases
Fre1/Fre2

Extracellular Reduces.Cu(II).to.Cu(I).for.uptake Georgatsou.et.al..(1997),.

Hassett.and.Kosman.(1995)

Copper.Transporters.(Ctr)
Ctr1

Plasma.membrane High.afinity.Cu(I).inlux COPT1.( Arabidopsis

thaliana )

Dancis.et.al..(1994)

Ctr2 Vacuole.

membrane?

Releases.stores.of.copper.from.
vacuole

Kampfenkel.et.al..(1995),.
Portnoy.et.al..(2001),.
Rees.et.al..(2004)

Ctr3 Plasma.membrane High.afinity.Cu(I).inlux Knight.et.al..(1996)

P-type.ATPase.Transporters
Ccc2 Golgi.membrane Uptake.of.copper.from.cytosol.to.

endomembrane.system.for.
incorporation.into.Fet3.for.iron.
uptake

RAN1( A. thaliana ) Yamaguchi.et.al..(1996)

Copper.Chaperones
ATX1 Cytoplasm Interacts.with.Ccc2 Atx1.( Synechocystis ) Lin.et.al..(1997)

Atx1.( A. thaliana )
CCH.( A. thaliana )

CCS Cytoplasm Transports.Cu(I).from.cell.

membrane.to.SOD1.(Cu,Zn.SOD)

CCS.( A. thaliana ) Schmidt.et.al..(1999a,b)

(continued)