The Role of Serotonin in Axon and Dendrite Growth - International Review of Neurobiology - page 113

Table 4.1 Summary of the effects of 5HT and its receptor subtypes manipulations on neurite, dendrite, and axon growth or guidance

Effected
target

Manipulation Species Neuron type Model system Effect References

5-HT Snail

Helisoma

Ganglia neurons Neurite In vitro Decrease Haydon et al. (1984) and

Goldberg et al. (1991)

5-HT Lymnaea

stagnalis

Cerebral giant cells Neurite In vitro Decrease Koert et al., 2001

5-HT Goldfish Retinal ganglion cells Neurite Ex vivo Decrease Lima et al. (1994)

5-HT Goldfish Retinal ganglion cells Neurite In vivo Decrease Lima et al. (1996)

5-HT Embryonic

rat

Serotonergic neurons Neurite In vitro Decrease Liu and Lauder (1991)

5-HT Embryonic

rat

Cortical neurons Neurite In vitro Decrease Sikich et al. (1990)

Fluoxetine Rat Cortical neurons Neurite In vitro Decrease Xu et al. (2010)

5-HT Embryonic

mouse

Thalamic neurons Neurite In vitro Increase Persico et al. (2006)

5-HT Postnatal rat Purkinje cells Dendrite Ex vivo Increase/decrease Kondoh et al. (2004)

5-HT Mammalian

cell line

PC12 cells Neurite In vitro Increase Homma et al. (2006) and

Severin and Kondratyev (1988)

5-HT Mammalian

cell line

Neuro 2A cells Neurite In vitro Increase Fricker et al. (2005)

Continued