The Role of Serotonin in Axon and Dendrite Growth - International Review of Neurobiology - page 114

Effected
target Manipulation Species Neuron type Model system Effect References

In vivo KO

MAOA Adult mouse Retinal ganglion

cells, thalamic
neurons

Axon Altered guidance Cases et al. (1995, 1996) and

Upton et al. (1999)

5-HTT;
SERT

Adult mouse Retinal ganglion
cells, thalamic
neurons

Axon In vivo KO Altered guidance Salichon et al. (2001)

PCPA Rat Cortical neurons Dendrite In vivo Decrease Vitalis et al. (2007)

Htr1A Embryonic

rat

Cortical neurons Neurite In vitro Decrease Sikich et al. (1990)

Htr1A Goldfish Retinal ganglion cells Neurite Ex vivo Decrease Lima et al. (1994)

Htr1A Embryonic

mouse

Thalamic neurons Neurite In vitro Increase Persico et al. (2006)

Htr1A Mammalian

cell line

Neuro 2A Neurite In vitro Increase Fricker et al. (2005)

Htr1A Postnatal rat Purkinje cells Dendrite Ex vivo Increase Kondoh et al. (2004)

Htr1A Embryonic

mouse

Serotonergic neurons Neurite Ex vivo No effect Dudok et al. (2009)

Htr1B Embryonic

mouse

Thalamic neurons Neurite In vitro Increase Lotto et al. (1999) and Persico

et al. (2006)

Htr1B Mouse Retinal ganglion

cells, thalamic
neurons

Axon In vivo Htr1B KO

in 5-HTT or
MAOA KO mice

Reduces guidance
alteration

Salichon et al. (2001) and
Upton et al. (2002)