Chemistry Reference
In-Depth Information
(
Continued
)
Polyvinyl Alcohol
High viscosity
200,000
Medium viscosity
130,000
Low viscosity
20,000
Polyvinylpyrrolidone-vinyl Acetate
Structure
H
CH
CH
2
C
CH
2
n
= 1.2
m
N
O
O
O
C
CH
3
n
m
Synonyms
PVP/VA, copovidone, polyvinylpyrrolidone-
co
-
vinyl acetate, copolyvidone, copovidonium,
Kollidon VA 64, Plasdone S-630
Molecular weight range (g/mol)
45,000
-
70,000
(MPa
0.5
)
Solubility parameter,
δ
25.6
T
g
range (
C)
106
°
Water uptake (% water at 50% RH)
10%
Solvent solubility
Soluble in 1,4-butanediol, glycerol, butanol,
chloroform, dichloromethane, ethanol (95%),
glycerol, methanol, polyethylene glycol 400,
propan-2-ol, propanol, propylene glycol; insoluble
in cyclohexane, diethyl ether, liquid paraf
n, and
pentane
pH range where soluble
1-10
Amenable methods of dispersion
manufacture
Melt extrusion, spray drying
Kaletra
, Norvir
, Onmel
Use in marketed products
