Agriculture Reference
In-Depth Information
Table 8.1.
Continued
Animal species/category
(animals per treatment
and duration of study)
Plant species/trait
Parameters measured
Main results
Authors' interpretation of results
References
Glyphosate
tolerant (
CP4-
EPSPS
gene)
Cv. 90B72
(near-isogenic
line)
F344/Du Crj (Fischer)
rats
(GM and non-GM-diet:
50/sex; standard CE-2
diet: 35/sex)
Feed intake. Growth. Organ weight.
Haematology, serum. Neoplastic
and non-neoplastic lesions. Bile
duct proliferation. Basophilic, clear
and eosinophilic altered
hepatocellular foci. Chronic
nephropathy.
Minor differences between GM- and
non-GM-fed males and between
GM- and non-GM-fed females in
some haematological parameters.
Safe, no long-term effects.
Sakamoto
et al
.,
2008
104 weeks
Glyphosate
tolerant (
CP4-
EPSPS
gene)
Salmon
(24)
Growth. Body weight. Organ
development. Histology.
Haematology, plasma enzymes
and nutrients. mRNA transcription.
Differential white blood cell count.
No growth differences. Glycogen
deposits in liver decreased in the
GM-fed fi sh. Minor differences
observed between the diet
groups.
Safe, no long-term effects.
Sissener
et al
.,
2009
7 months
(28 weeks)
Glyphosate
tolerant (
CP4-
EPSPS
gene)
Atlantic salmon
(20)
Enzyme activities of maltase, leucine
aminopeptidase, acid
phosphatase (AcP) and fructose-
1,6-bisphosphatase activity.
Transport activity and protein
expression in intestinal brush
border membrane vesicles.
Endocrine pancreatic response.
Lysozyme levels. Total amount of
immunoglobulin M.
The increased AcP activity reported
in GM soybean-fed fi sh most
likely due to increased
macrophage infi ltration. Highest
values in intestinal Na
+
-
dependent D-glucose uptake and
SGLT1 protein level in the region
pyloric caeca found in GM,
intermediate in the non-GM and
lowest in the standard fed groups.
Atlantic salmon parr appear to
tolerate a 12.5% inclusion level
of full-fat soybean meal. GM
soybeans at inclusion levels of
up to 6% appear to be as safe
as counterparts. Differences
due to origin as well as heat
treatment of the non-GM
soybean varieties.
Bakke-McKellep
et
al
., 2008
8 months
(32 weeks)
(No isogenic line
compared to
GM soybean)
