Long-term and Multi-generational Animal Feeding Studies - Animal Nutrition with Transgenic Plants - page 115

Animal species/category
(animals per treatment
and duration of study)

Plant species/trait Parameters measured Main results Authors' interpretation of results References

Bt-MON810
( cry1Ab gene)

Atlantic salmon parr
(20)

Enzyme activities of maltase, leucine
aminopeptidase (LAP) and acid
phosphatase (AcP). Transport
activity and protein expression in
intestinal brush border membrane
vesicles. Endocrine pancreatic
response. Lysozyme activity.
Immunoglobulin M.

No differences between GM and
non-GM feed. GM and non-GM
diets result in higher LAP activity
compared to standard diet.
Activity of maltase and AcP
highest in standard diet.

The two GM varieties at inclusion
levels of up to 6% (ingredient)
appear to be as safe as the
two counterparts.

Bakke-McKellep et
al ., 2008

8 months
(32 weeks)

Rice
7Crp#10 ( 7Crp
gene derived
from cedar
pollen Cryj I
and Cryj II
allergen protein
genes)

Macaques
(11/sex)

Gross necropsy, histopathology and
absolute and relative organ
weights. Blood composition
(haematology; blood
biochemistry).

No signifi cant differences in
haematological or biochemical
values between treatment groups
(a high dose of GM rice, a low
dose of GM rice and a high dose
of the parental rice strain).

No adverse effects on behaviour
or body weight, haematological
and biochemical variables.
Neither pathological symptoms
nor histopathological
abnormalities observed.

Domon et al ., 2009

182 days
(26 weeks)

Soybean
Glyphosate
tolerant ( CP4-
EPSPS gene)

Wistar rats
(10 males)

Growth. Blood composition. No signifi cant differences between

GM group and organic group.

Safe, no long-term effects. Daleprane et al .,

2009a

455 days
(65 weeks)

Glyphosate
tolerant ( CP4-
EPSPS gene)

Wistar rats
(10)

Aorta wall tissue. Cholesterol,
triaclyglycerol, insulin, glucose
and testosterone.

Lower body weight and fat mass in
control. Cholesterol,
triaclyglycerol, glucose and aortic
tunics reduced in non-GM and
GM.

Safe, no long-term effects. Daleprane et al .,

2010

455 days
(65 weeks)

Glyphosate
tolerant ( CP4-

F344/Du Crj (Fischer)
rats

Feed intake. Growth. Organ weight.
Haematology, serum. Histology.

Minor differences between GM- and
non-GM-fed males in some blood

Safe, no long-term effects. Sakamoto et al .,

2007