Biomedical Engineering Reference
In-Depth Information
TABLE 18.2
(
Continued
)
Structure
Name
Activity
Assay
Ref.
Macrolactam BRD-4805
HDAC inhibitor; IC
50
=
2.7
MforHDACs1,3;
IC
50
=
6.6
M for
HDAC 2
Histone deacetylase
biochemical functional
assay with fluorescent
readout
48
MAL3-101-
dihydropyrimidinone
Fourfold decrease in
TAg-stimulated Hsp70
ATPase activity at 0.3
mM
TLC separation of
radiolabeled ATP and
ADP
22,49
