Biomedical Engineering Reference
In-Depth Information
Tetrahydropyridine
P61-E7
Protein
geranylgeranylation
inhibitor, at 5
M;
21-fold increase in
unprenylated Rap1
Detection of
unprenylated Rap1 by
immunoblotting analysis
38
Tetrasubstituted
cyclohexene analog
Bcl-x
L
inhibitor
NMR-based binding
assay
39
2-Hydroxybenzimidazole
analog
Phospholipase D
subtype 1 inhibitor;
IC
50
=
11 nM in vitro
Release of
[methyl-
3
H]choline
from labeled DPPC
40
Benzimidazole analog
Gonadotropin-releasing
hormone (GnRH)
antagonist;
IC
50
=
50 nM
In vitro screen with
radioactively labeled
GnRH
41
(
continued
)
