Biomedical Engineering Reference
In-Depth Information
TABLE 18.2
(
Continued
)
Structure
Name
Activity
Assay
Ref.
-exo-Methylene-
-
Homoserine
transacetylase (HTA)
inhibitor; IC
50
=
140
M
In vitro monitoring of
CoA production
42
lactam
analog
Macrocycle robotnikinin
Hedgehog pathway
inhibitor;
K
d
=
3.1
M
binding to ShhN
Small-molecule
microarray binding
screen
43
Tricyclic pyridone analog
Bcl-2 inhibitor;
K
i
=
1.2
M
Competition binding
assay
44
