Biomedical Engineering Reference
In-Depth Information
Retrosyntheti
c
Simple
Complex
Analysis
Focused (Combinatorial) Library Synthesis:
Similar
Target
Structures
Retrosyntheti
c
Complex &
Similar
Simple
Analysis
Diversity-Oriented Synthesis:
Diverse
Target
Structures
Forward
Synthetic
Simple &
Similar
Complex &
Diverse
Analysis
FIGURE 1.1
Planning strategies and end goals involved in target-oriented synthesis, focused
library synthesis (combinatorial synthesis), and diversity-oriented synthesis. The first two
approaches use retrosynthetic analysis to design the synthesis of target compounds. DOS uses
forward synthetic analysis to produce libraries that occupy diffuse regions of chemical space.
