Biomedical Engineering Reference
In-Depth Information
TABLE 5.12 Synthesis of Indanyl- (39b) and Cyclopentaindolyl Amides (39c)
Entry
Nitrile
R (40)
Yield (%)
a,b
Purity
c
1
36b
i
-Pr
40
100
2
36b
CH
3
(CH
2
)
8
64
100
3
36b
MeOCH
2
18
100
4
36b
PhOCH
2
33
100
5
36b
4-OMe-Bn
40
100
6
36b
4-F-Bn
17
99
7
36b
Ph(CH
2
)
2
54
100
8
36b
4-CF
3
-Ph
27
100
9
36c
i
-Pr
14
99
10
36c
4-OMe-Bn
19
100
11
36c
Ph(CH
2
)
2
14
96
a
Isolated yield.
b
10 : 1, anti : syn.
c
UV 214 nM.
>
1
SCHEME 5.16
Representative
-hydroxyamides
41a
and
b
. (Adapted from [18], with per-
mission; copyright
C
2009 American Chemical Society.)
