Biomedical Engineering Reference
In-Depth Information
2.5
(c) Buschmann et al. (1999), 0.01 Hz at 10% strain
2
10
-5
mg/mL/sec)
Numberical solution (
λ
= 2
×
Numberical solution (λ = 1 × 10
-5
mg/mL/sec)
1.5
1
Numberical solution (
λ
= 0 mg/mL/sec)
0.5
Experimental data
0
0
0.2
0.4 0.6
Radial distance from the center of cartilage (mm)
0.8
1
1.2
2.5
(d) Buschmann et al. (1999), 0.01 Hz at 10% strain
2
10
-5
mg/mL/sec)
Numberical solution (
λ
= 2
×
1.5
Numberical solution (λ = 1 × 10
-5
mg/mL/sec)
1
Numberical solution (λ = 0 mg/mL/sec)
0.5
Experimental data (Buschmann et al. 1999)
0
0
0.2
0.4 0.6
Radial distance from the center of cartilage (mm)
0.8
1
1.2
FIGURE 11.17
(Continued)
provide a remarkably good fit with all three sets of experimental data by
using least squares optimization. Figure 11.17a shows that there is no obvi-
ous aggrecan production if IGF-I concentration is less than certain threshold
(i.e., 10 ng/mL) but the production can be rapidly “switched on” once IGF-I
concentration is over this threshold. It can be seen from Figure 11.17c-d that
a loading regime of high frequency (i.e., 0.1 Hz) stimulates aggrecan biosyn-
thesis only at the peripheral region, while the region experiencing mechanical
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