The Transport of Insulin-Like Growth Factor through Cartilage - Porous Media: Applications in Biological Systems and Biotechnology - page 441

concentration c a 0 . A key challenge here is to reproduce the experimental out-
come using a single set of parameters.
As shown in Figure 11.17, with the adoption of the aforementioned set
of parameters in the theoretical model (Table 11.4), the numerical solutions

3.5

(a) Bonassar et al. (2000)

3

2.5

2

Numberical solution

1.5

1

Experimental data

0.5

0

0.1 1 10

IGF-I concentration (ng/mL)

100 1000

2.5

(b) Jin et al. (2003)

Numberical solution

2

1.5

1

Experimental data

0.5

0

0 50 100 150

IGF-I concentration (ng/mL)

200 250 300

FIGURE 11.17
Comparison of model predictions with three independent experimental results
[30-32]. Note the set of model parameters is identical in each case. ( Continued )